Robert Lewandowski scored twice with Lamine Yamal and Raphinha also getting on the scoresheet as Barcelona thrashed Real Madrid away to extend their lead over the bitter rivals to six points at the top of LaLiga.
Kylian Mbappe, playing in his first-ever El Clasico, had efforts in each half ruled out for offside on a shocking night for the hosts in the Spanish capital.
- As it happened: How Barcelona silenced the Bernabeu
- Teams | Match stats: Dominant Barca embarrass Real Madrid
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Lewandowski missed two gilt-edged opportunities to get what would have been a famous hat-trick, before Jude Bellingham and Mbappe spurned opportunities to get Real Madrid back in the game.
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Lewandowski was also involved in Barcelona's third goal which saw Yamal crash home to net his first El Clasico goal, before Raphina chipped Andriy Lunin late on to add insult to injury on an embarrassing night for the home side.
Real open investigation into alleged racist abuse of Yamal
Videos on social media appear to show 17-year-old Yamal being subjected to taunts by a section of home fans as he celebrated his 77th-minute goal by pointing to his name on the back of his shirt.
"Real Madrid strongly condemns any kind ofbehaviour involving racism, xenophobia or violence in football and sport, and deeply regrets the insults that a few fans uttered last night in one of the corners of the stadium.
"Real Madrid has opened an investigation in order to locate and identify the perpetrators of these deplorable and despicable insults so that the appropriate disciplinary and judicial measures can be taken."
LaLiga added in a statement: "LaLiga will immediately report the racist insults and gestures received by Barcelona players to the Hate Crimes Section of the National Police Information Brigade, as well as informing the Coordinating Prosecutor of the Hate Crimes and Discrimination Unit of the State Attorney General's Office."
"LaLiga vehemently condemns the incidents at the Santiago Bernabeu and remains firm in its commitment to eradicate any kind of racist behaviour and hatred inside and outside stadiums."
Barcelona thrash Real Madrid - in pictures
Barcelona striker Lewandowski opened scored from a superb pass by Marc Casado in the 54th minute and headed in a second goal three minutes later to silence the Santiago Bernabeu.
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Those were goals No 16 and 17 overall for the Poland striker this season, taking his league-best tally to 14. He also hit the post.
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Yamal made it a rout in the 77th minute when the teenage phenom rifled a shot from an angle over Lunin.
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Raphinha got involved in the burgundy-and-blue party when he broke free with Madrid pressing forward and chipped Lunin in the 84th minute.
Mbappe had a frustrating first game against Barcelona in a white shirt.
The France star was repeatedly caught offside by Barcelona's synchronised back four and failed to beat second-choice goalkeeper Inaki Pena one-on-one with his team down by two goals.
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Hansi Flick, meanwhile, had a night to remember in the first Clasico for the German coach. Barcelona opened a six-point lead at the top of LaLiga over second-placed Madrid after 11 round of fixtures.
Ancelotti: Real Madrid can still win LaLiga, CL
Real Madrid boss Carlo Ancelotti: "I've been worried about the defeat. We have to pick ourselves up quickly and correct the mistakes of the second half. We have to keep competing and fighting.
"We will continue to do so this season as we did last season. In the last defeat against Barcelona with 4-0 we won the league and the Champions League. We won't be far off last season's achievements."
Flick: I am proud of Barcelona
Barcelona boss Hansi Flick: "We started the journey, we prepare for each game and we love to do things well. It was not easy, but we have to continue on the path. We defended well and we did a good job.
"I'm very proud of the team and that all the players worked one hundred per cent."
Flick discusses full-time spat with Ancelotti
Ancelotti said after the game: "I didn't argue with Hansi Flick, I got angry with one of his staff. He made gestures towards our bench, he didn't act like a gentleman."
Responding to Ancelotti's claims, Flick replied: "I haven't seen [footage of his assistant].
"I've spoken to [Ancelotti], but it's a normal situation. We celebrated the goal. We're adults enough to talk about this."
What's coming up in LaLiga?
- Real Madrid fixtures
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